Tipranavir AUC ↑ 66%. Tipranavir Cmin ↑ 100%. CYP 3A4 hämning genom tipranavir/r och P-gp (en efflux transportör i tarmen) hämning genom klaritromycin .

ASM. Antimicrobial Agents and Chemotherapy; Applied and Environmental Microbiology; Clinical Microbiology Reviews; Clinical and Vaccine Immunology; EcoSal Plus

At the single cell level, it is becoming apparent that the use of efflux pumps is the first line of defence against an antibiotic, as these pumps decrease the intracellular level of antibiotic while the cell activates the various other levels of protection. • Vesicular transport assays for efflux transporter inhibition A family of ATP binding cassette (ABC) transporters is an important group of membrane transporters involved in drug absorption, distribution and elimination. Efflux pumps are proteinaceous transporters localized in the cytoplasmic membrane of all kinds of cells. They are active transporters, meaning that they require a source of chemical energy to perform their function.

Efflux transportör

Effluxpumpe ist ein veralteter Name für Membran-ATPasen und Membrantransporter (Carrier), die Moleküle aus der Zelle hinaus befördern. Diese Proteine kommen in allen Lebewesen vor. Many translated example sentences containing "efflux transporter" – German-English dictionary and search engine for German translations. Efflux cell membrane transporters are not only responsible for moving the parent drug and metabolites of some medications out of the cell, but may also contribute to drug resistance by diminishing the desired therapeutic or biologic effect.2 As such, anything that prevents or inhibits a medication from being transported out of certain cells could result in excessive blood concentrations of the The studies reported here were conducted to investigate the transport characteristics of apixaban (1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide) and to understand the impact of transporters on apixaban distribution and disposition. In human permeability glycoprotein (P-gp)- and breast cancer resistance protein (BCRP Efflux carriers are mainly represented by the ATP-binding cassette (ABC) family of transmembrane transporters. Their driving force is provided by the hydrolysis of ATP so that substrates can be Enligt EU-lag vill vi informera dig om att vår webbplats använder cookies med syfte att ge dig en upplevelse av högsta kvalitet. Du kan ställa in hur cookies skall lagras i inställningarna för din webbläsare.

efflux n noun: Refers to person, place, thing, quality, etc. (law: expiration of time period) expiración del plazo loc nom f locución nominal femenina: Unidad léxica estable formada de dos o más palabras que funciona como sustantivo femenino ("casa de citas", "zona cero", "arma secreta").

Vi presenterar en metod som ämnen kräver funktionella uttryck för upptag och efflux transportörer 3. blod-till-hjärnan transport av särskilda Oatp transport substrat såsom Genes, MDR. MDR-gener. Svensk definition.

För att bestämma aktiv transport applicerades 3 H-SUL, som är strukturellt relaterat till speciellt lipofila läkemedel som inte är substrat av en efflux-transportör.

Å være mer kjent med detaljene i funksjonell dynamikk og konformasjoner av disse typer pumper kan bidra til å oppdage tilnærminger for å hindre at de fungerer som de skal. Traducciones en contexto de "efflux" en inglés-español de Reverso Context: The ABCA1 transporter is involved in the efflux of cholesterol and phospholipids to lipid-poor lipoproteins.

Tipranavir Cmin ↑ 100%.
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ÖNERİ 2 Bazolateral hücresel iyot uptake ve iyot apikal akışı (efflux) yarı net tiroid hormon transportu tipik olarak bir dizi farklı transportör aktivitelerinin 11 Ara 2019 heme taşıma proteinini kodlayan phuUVW ABC transportör bağlantılı Ganz T , Kaplan J. Hepcidin regulates cellular iron efflux by binding to 12 Kas 2019 den dışarıya aktarılıyorsa dışa-atım (“efflux”)'dan söz edi bi İlaç taşıyıcı ( transportör} proteinlerin leri içeren hücrelerde in vitro, ya da 5 Eki 2014 (efflux) yarı geçirgen membran üzerinde kültürize edilerek iki-bölmeli olarak bir dizi farklı transportör aktivitelerinin toplamını ifade eder. (MDR) -genproduktet P-glykoprotein (Pgp), en multidrug-efflux-transportör. intracellulär ackumulering och cellulär efflux med användning av HB8065 / R 6 maj 2019 bl.a.

Definition. Mit dem Begriff Efflux bezeichnet man den Ausstrom von Ionen oder Molekülen aus der Zelle Krishnamurthy et al: Efflux transporters in the pathogenesis of hydrocephalus 367 www.cmj.hr Hydrocephalus is a common brain disorder that affects chil-dren and individuals of all ages. It is the most common con-genital abnormality in children (one out of 500 births) (1). If left untreated, hydrocephalus can lead to permanent brain d’efflux Composés endogènes ou exogènes variés Défense de l’organisme Diversité des transporteurs Blood pH=7.2 CNT PepT1 OATP MRP3 MRP1 OCT P-gp BCRP MRP2.
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Narkotika som riktar sig mot transportörer kan delas in i två typer baserat på en väsentligen långsammare hastighet av DAT-medierad efflux jämfört med fullt

Du kan ställa in hur cookies skall lagras i inställningarna för din webbläsare. 2013-04-01 Krishnamurthy et al: Efflux transporters in the pathogenesis of hydrocephalus 367 www.cmj.hr Hydrocephalus is a common brain disorder that affects chil-dren and individuals of all ages. It is the most common con-genital abnormality in children (one out of 500 births) (1). If left untreated, hydrocephalus can lead to permanent brain Efflux cell membrane transporters are not only responsible for moving the parent drug and metabolites of some medications out of the cell, but may also contribute to drug resistance by diminishing the desired therapeutic or biologic effect.2 As such, anything that prevents or inhibits a medication from being transported out of certain cells could result in excessive blood concentrations of the efflux transporters: Abbreviation Variation Long Form Variation Pair(Abbreviation/Long Form) Variation No. Year Title Co-occurring Abbreviation; 1 : 2019: An update on polyphenol disposition via coupled metabolic pathways.